Effect of semi-permanent double-lumen central venous catheter on micro-inflammatory state in maintenance hemodialysis patients

doi:10.3969/j.issn.2095-4344.2013.05.023

Abstract

Abstract:

BACKGROUND: Semi-permanent double-lumen central venous catheter as an important supplement of autogenous arteriovenous fistula has been widely used in maintenance hemodialysis patients. But the studies have found that the mortality rate of semi-permanent double-lumen central venous catheters used for hemodialysis vascular access is higher than that of autogenous arteriovenous fistula. The reason is not clear. At present, the effect of different types of vascular access on the micro-inflammatory state is rarely reported.
OBJECTIVE: To compare the different levels of inflammation factors in maintenance hemodialysis patients with semi-permanent double-lumen central venous catheter and arteriovenous fistula, and to explore the effect of the hemodialysis vascular access types on the micro-inflammation in maintenance hemodialysis patients.
METHODS: Eighty patients with uremia underwent maintenance hemodialysis were selected, and divided into autologous arteriovenous fistula group (n=48) and semi-permanent double-lumen central venous catheter group (n=32) according to different vascular access types. Sixty healthy people were selected as normal control group. The serum high sensitivity C-reactive protein, interleukin-6 and tumor necrosis factor-α of the maintenance hemodialysi group and the normal control group were detected.
RESULTS AND CONCLUSION: The serum high sensitivity C-reactive protein, interleukin-6 and tumor necrosis factor-α of the maintenance hemodialysis patients were significantly higher than those of the normal control group (P < 0.01). The serum high sensitivity C-reactive protein, interleukin-6 and tumor necrosis factor-α in the semi-permanent double-lumen central venous catheter group were higher than those in the autologous arteriovenous fistula group (P < 0.05). Micro-inflammatory state exists in maintenance hemodialysis patients, and the utilization of semi-permanent double-lumen central venous catheter as hemodialysis vascular access can aggravate the micro- inflammatory state as compared with the utilization of autologous arteriovenous fistula.

Key words: organ transplantation, basic experiments of organ transplantation, semi-permanent double-lumen central venous catheter, autologous arteriovenous fistula, maintenance hemodialysis, healthy control, inflammatory cytokines, high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor alpha, microinflammatory state, provincial grants-supported paper

CLC Number:

R318

Zhang Xiao-dong, Li Xiao-ping, Song Jie, Li Ying1, Li Hui. Effect of semi-permanent double-lumen central venous catheter on micro-inflammatory state in maintenance hemodialysis patients[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(5): 913-919.

Figures/Tables 4

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